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Central Interleukin‐1 Receptors as Mediators of Sickness a
Author(s) -
KELLEY KEITH W.,
HUTCHISON KEVIN,
FRENCH RICHARD,
BLUTHÉ ROSEMARIE,
PARNET PATRICIA,
JOHNSON RODNEY W.,
DANTZER ROBERT
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48395.x
Subject(s) - central nervous system , receptor , immunology , neuroscience , interleukin , inflammation , disease , medicine , cytokine , biology
These data establish that cytokines, such as IL-1, can act on specific receptors within the brain to induce many symptoms of sickness. A number of inflammatory stimuli in the periphery can activate both the transcription and translation of IL-1 within the central nervous system. It will now be important to determine if similar central IL-1 pathways are activated during SLE and whether these central inflammatory cytokines are involved in the neurologic complications that often accompany this disease.