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Cerebral Lupus Vasculopathy
Author(s) -
HESS DAVID C.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48388.x
Subject(s) - annals , citation , neurology , service (business) , medicine , library science , clinical neurology , gerontology , psychology , classics , history , psychiatry , computer science , neuroscience , business , marketing
The most common neuropathological findings in SLE are a small vessel cerebral vasculopathy and microinfarcts. These findings may reflect the end result of repeated episodes of acute inflammation in the small vessels in the brain. There is experimental support for the local Shwartzman reaction as a paradigm to explain some of the CNS manifestations in SLE. Activation or "priming" of cerebral microvascular endothelial cells by anticardiolipin antibodies or other immunoglobulins in concert with intravascular activation of the complement system may combine to elicit leukothrombosis in the brain. Therapies aimed at inhibiting leukocyte-endothelial cell interactions in the brain may be of use in CNS lupus.