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Heterogeneity of 5‐HT Receptors Mediating Secretion in the Human Intestine a
Author(s) -
BORMAN R. A.,
BURLEIGH D. E.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48183.x
Subject(s) - queen (butterfly) , annals , classics , art , biology , zoology , hymenoptera
In conclusion, application of 5-HT has been shown to induce fluid secretion in both the small and large intestine of man. By the use of selective antagonists, the receptors mediating these effects have been identified and characterized. 5-HT induces secretion across human ileal mucosa via a receptor of the 5-HT4 sub-type, whereas a receptor of the 5-HT2A sub-type appears to mediate the effect in human sigmoid colon. The response in human ascending colonic mucosa cannot be definitively classified at this time, but may reflect the presence of a heterogenous receptor population.