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5‐HT 1D and 5‐HT 2B Receptors Mediate Contraction of Smooth Muscle in Human Small Intestine
Author(s) -
BORMAN R. A.,
BURLEIGH D. E.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb48182.x
Subject(s) - queen (butterfly) , annals , theology , art , classics , philosophy , biology , zoology , hymenoptera
In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of the 5-HT1D sub-type, whereas a receptor of the 5-HT2B sub-type mediates the contractile response to 5-HT of longitudinal muscle layers.