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Near‐Infrared Imaging and Spectroscopy in Stroke Research: Lipoprotein Distribution and Disease a
Author(s) -
DEMPSEY R. J.,
CASSIS L. A.,
DAVIS D. G.,
LODDER R. A.
Publication year - 1997
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1997.tb46194.x
Subject(s) - medicine , library science , gerontology , medical school , pharmacy , family medicine , medical education , computer science
Stroke is a critical problem in the United States that affects more than 500,000 people annually. Research into the causes of stroke and testing of drug therapies to reduce ischemic and postischemic damage to the brain is hampered by an inability to continuously follow the physical and chemical events that occur during ischemia and reperfusion in vivo. Near-infrared (near-IR) spectrometry has recently been used to observe stroke-induced changes in the lipids and proteins of whole brain samples in vitro and in viva I The examination of whole brains was made possible by a combination of hardware and software techniques designed to make the sample presentation to the spectrometer more reproducible. Near-IR spectrophotometry of gerbil brain tissue discriminated between adult (3-4 months of age) and aged (1 8-20 months of age) brains as well as between brains exposed to 5 and 10 minutes of ischemia. The near-IR analytical method has many applications in aging and stroke research, including the noninvasive determination of age from brain spectra obtained transcranially, simultaneous multicomponent analysis of lipids and proteins, and quantification of stroke-induced edema. More recently, near-IR research has moved to the events preceding ischemic injury. Arterial disease contributes to most of the deaths in the United States. Epidemiological studies performed over a period of years have indicated that reduction of blood cholesterol levels significantly reduces the risk of atherosclerosis, ischemia, myocardial infarction and death. For some time these data have been cited in experimental attempts to prevent arterial disease. One