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Enteropathogenic E. coli Exploitation of Host Epithelial Cells a
Author(s) -
FINLAY B. BRETT,
RUSCHKOWSKI SHARON,
KENNY BRENDAN,
STEIN MARKUS,
REINSCHEID DIETER J.,
STEIN MURRY A.,
ROSENSHINE ILAN
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb52946.x
Subject(s) - intimin , enteropathogenic escherichia coli , cytoskeleton , epithelium , microbiology and biotechnology , biology , secretion , lesion , cell , cell membrane , signal transduction , escherichia coli , enterobacteriaceae , pathology , medicine , biochemistry , genetics , gene
Enteropathogenic E. coli (EPEC) is a leading cause of neonatal diarrhea worldwide. These organisms adhere to the intestinal cell surface, causing rearrangement in the epithelial cell surface and underlying cytoskeleton, resulting in a structure termed an attaching/effacing (A/E) lesion. A/E lesion formation is thought necessary for EPEC-mediated disease. EPEC secretes several proteins that trigger signal transduction, intimate adherence, and cytoskeletal rearrangements in epithelial cells. Additionally, it produces intimin, an outer membrane product that mediates intimate adherence. Together these various bacterial molecules contribute to the intimate relationship that is formed by EPEC with host epithelial cells which results in A/E lesion formation and diarrhea.