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The ATPase Module and the Process of Cellular Immortalization
Author(s) -
KRØLL J.
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb39051.x
Subject(s) - atp synthase , mitochondrion , atpase , microbiology and biotechnology , enzyme , v atpase , phenotype , chemistry , biochemistry , biology , gene
The phenotype of normal aging is proposed to result from a progressive decrease in the functional capacity of the mitochondrion as the main supplier of the universal currency of bioenergy, ATP. It is suggested that this aging-related mitochondrial dysfunction specifically concerns the ATPase module of the ATP synthase enzyme complex. Evidence in support of this proposal is reviewed.