Premium
Amyloid β‐Protein Induces the Cerebrovascular Cellular Pathology of Alzheimer's Disease and Related Disorders a
Author(s) -
NOSTRAND W. E.,
DAVISSALINAS J.,
SAPORITOIRWIN S. M.
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb34436.x
Subject(s) - cerebral amyloid angiopathy , beta (programming language) , pathology , amyloid beta , amyloid (mycology) , biochemistry of alzheimer's disease , alzheimer's disease , amyloid precursor protein , medicine , chemistry , biology , disease , dementia , computer science , programming language
One of the hallmark pathologic characteristics of Alzheimer's disease (AD) and related disorders is deposition of the 39–42 amino acid amyloid β‐protein (Aβ) in the walls of cerebral blood vessels. The cerebrovascular Aβ deposits in these disorders are associated with degenerating smooth muscle cells in the vessel wall which have been implicated in the expression of the amyloid β‐protein precursor (AβPP) and formation of Aβ. We have established primary cultures of human cerebrovascular smooth muscle cells as a model for investigating the cellular pathologic processes involved in the cerebral amyloid angiopathy of AD and related disorders. Recently, we have shown that Aβ 1‐42, the predominant pathologic cerebrovascular form of Aβ, causes extensive cellular degeneration that is accompanied by a striking increase in the levels of cellular AβPP, potentially amyloidogenic carboxyl terminal AβPP fragments, and soluble Aβ peptide in the cultured human cerebrovascular smooth muscle cells. Together, these studies provide evidence that Aβ contributes to the onset and progression of the cerebrovascular pathology associated with AD and related disorders and suggests the mechanism involves a molecular cascade with a novel product‐precursor relationship that results in the adverse production and accumulation of Aβ.