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Clinical and Neuroimaging Features of Familial Alzheimer's Disease a
Author(s) -
ROSSOR M.N.,
KENNEDY A.M.,
FRACKOWIAK R.S.J.
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb34400.x
Subject(s) - neuroimaging , pedigree chart , asymptomatic , positron emission tomography , allele , disease , alzheimer's disease , mutation , medicine , genetics , pathology , neuroscience , psychology , biology , gene
Subtle phenotypic differences between familial Alzheimer's disease (FAD) pedigrees can be identified which may reflect the genetic and allelic heterogeneity of the disease. Positron emission tomography (PET) of APP mutation and chromosome 14‐linked FAD pedigree members reveals biparietal bitemporal hypometabolism. Scanning of asymptomatic at‐risk individuals reveals a similar, but quantitatively less severe, pattern of hypometabolism.