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Antibody Production and Engineering in Plants
Author(s) -
MA JULIAN KC.,
HEIN MICH B.
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb32493.x
Subject(s) - heterologous , production (economics) , antibody , microbiology and biotechnology , protein engineering , investment (military) , biochemical engineering , scale (ratio) , agriculture , gene engineering , recombinant dna , computer science , biology , engineering , economics , biochemistry , immunology , ecology , physics , quantum mechanics , politics , gene , law , political science , macroeconomics , enzyme
Plants have always been important in the pharmaceutical industry, and plant biotechnology now offers new applications. The use of heterologous expression systems for production of recombinant proteins including antibodies is no longer novel. Attention has now turned towards the end-user, and specifically to engineering the antibody to precise requirements. In expanding the choice of production systems, plants offer unique alternatives for antibody users not only in the bulk production of antibody molecules but also in the ability to assemble full-length and complex, multimeric antibodies. Although the initial investment of time and effort is substantial compared to that of other expression systems, antibody production on an agricultural scale can be envisioned, and the economy of this approach opens many new areas for potential antibody applications in addition to their traditional research and pharmaceutical uses.