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Mucosal Tolerance to Aflatoxin B 1 a
Author(s) -
OLIVER A. R.,
SILBART L. K.,
KEREN D. F.,
MILLER B.,
McDONALD R. A.
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb21162.x
Subject(s) - miller , library science , gerontology , medicine , biology , ecology , computer science
In an attempt to generate a secretory IgA (sIgA) immune response to the dietary carcinogen aflatoxin B1 (AFB), we coimmunized New Zealand white rabbits through chronically isolated ileal loops' with AFB coupled to porcine thyroglobulin (TG) and cholera toxin (CT), a potent mucosal adjuvant.2 This protocol resulted in a negligible sIgA anti-AFB response (FIG. l), in contrast to prior studies with conjugates made with the carcinogen 2-acetylaminofluorene.'" The sIgA anti-CT and anti-TG responses of animals immunized