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Cytokine‐dependent Modulation of Oral Tolerance in a Murine Model of Autoimmune Uveitis
Author(s) -
CASPI RACHEL R.,
STIFF LESLIE R.,
MORAWETZ R.,
MILLERRIVERO NANCY E.,
CHAN CHICHAO,
WIGGERT BARBARA,
NUSSENBLATT ROBERT B.,
III HERBERT C. MORSE,
RIZZO LUIZ V.
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb21139.x
Subject(s) - oral tolerance , immunology , immune tolerance , cytokine , medicine , regimen , immune system
In summary, our data suggest that oral tolerance in the mouse EAU model may occur by anergy/deletion or by suppression, depending on the feeding regimen. Tolerance involving putative regulatory cells appears to require the ability to produce both IL-4 and IL-10, whereas induction of tolerance involving anergy may not require the presence of Il-4 and IL-10. We propose that regulatory cells induced by three feedings of IRBP can be selectively enhanced through the use of cytokines. From the point of view of clinical therapy, it would be worthwhile to explore postimmunization feeding regimens involving administration of IL-4 and IL-10.