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PACAP Occurs in Sensory Nerve Fibers and Participates in Ocular Inflammation in the Rabbit a
Author(s) -
WANG ZUNYI,
ALM PER,
HÅKANSON ROLF
Publication year - 1996
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1996.tb17556.x
Subject(s) - neuropeptide , calcitonin gene related peptide , inflammation , sensory system , population , capsaicin , chemistry , ciliary body , neurogenic inflammation , sensory nerve , trpv1 , endocrinology , neuroscience , medicine , substance p , psychology , receptor , biochemistry , environmental health , transient receptor potential channel
PACAP is a sensory neuropeptide; it occurs together with CGRP in a population of C fibers in the rabbit eye. PACAP is likely to be involved in the inflammatory response in as much as PACAP-induced responses mimic the symptoms of inflammation and because the concentration of PACAP-LI in the aqueous humor increased greatly in response to noxious stimuli. The observation that capsaicin releases both PACAP and CGRP from the iris and ciliary body supports the view that PACAP is present in C fibers in the rabbit eye.