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Dual Receptor T‐Cells
Author(s) -
PADOVAN ELISABETTA,
CASORATI GIULIA,
DELLABONA PAOLO,
GIACHINO CLAUDIA,
LANZAVECCHIA ANTONIO
Publication year - 1995
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1995.tb44482.x
Subject(s) - monoclonal antibody , t cell receptor , receptor , microbiology and biotechnology , autoimmunity , antigen , antibody , biology , immunology , chemistry , t cell , immune system , biochemistry
Using monoclonal antibodies to human V alpha, we have estimated that up to one-third of mature T-cells express two V alpha chains as part of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor. We discuss the possibility that dual receptor T-cells may be involved in alloreactivity and autoimmunity.