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Cord Blood Transplantation and the Potential for Gene Therapy
Author(s) -
BROXMEYER HAL E.,
COOPER SCOTT,
ETIENNEJULAN MARYSE,
WANG XUSHAN,
PONNAZHAGAN SELVARANGAN,
BRAUN STEPHEN,
LU LI,
SRIVASTAVA ARUN
Publication year - 1995
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1995.tb31048.x
Subject(s) - genetic enhancement , transplantation , cord blood , medicine , gene , biology , immunology , genetics
Cord blood, which contains a high frequency of immature stem/progenitor cells with extensive proliferative and replating capacity in vitro was used as a clinical source of transplantable stem and progenitor cells. These cells can be efficiently transduced with new genetic material by using AAV or retroviral vectors. Using a recombinant AAV vector, high level expression of the lacZ gene under a CMV promoter was demonstrated in immature subsets of cord blood progenitor cells.