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Potential Approaches for Myocardial Regeneration a
Author(s) -
SOONPAA MARK H.,
DAUD ADIL I.,
KOH GOU YOUNG,
KLUG MICHAEL G.,
KIM KYUNG KEUN,
WANG HE,
FIELD LOREN J.
Publication year - 1995
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1995.tb17454.x
Subject(s) - regeneration (biology) , physics , biology , microbiology and biotechnology
Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited to cardiac transplantation. An increase in cardiomyocyte number in diseased hearts could improve function. Augmentation of the cardiomyocyte population may be achievable by the expression of regulatory proteins in the myocardium, or by intracardiac grafting of exogenous cardiomyocytes.