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Prenatal Determination of Fetal Rhesus D Status by DNA Amplification of Peripheral Blood of Rhesus‐Negative Mothers
Author(s) -
LO YM. D.,
BOWELL P. J.,
SELINGER M.,
MACKENZIE I. Z.,
CHAMBERLAIN P.,
GILLMER M. D. G.,
ELLIOTT P.,
PRATT G.,
LITTLEWOOD T. J.,
Fleming K. A.,
Wainscoat J. S.
Publication year - 1994
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1994.tb55774.x
Subject(s) - obstetrics and gynaecology , medicine , general hospital , university hospital , family medicine , pregnancy , biology , genetics
We have developed a sensitive PCR-based assay for the RhD gene and used it to detect circulating fetal cells from RhD-positive fetuses from peripheral blood of RhD-negative mothers. With further improvement in diagnostic accuracy, this assay may have implications in the management of RhD-sensitized pregnancies in women whose partners are heterozygous for the RhD gene. Further studies are required to determine the relationship between maternal anti-D levels and circulating fetal cell numbers.