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Lectin Effects on HIV‐1 Infectivity
Author(s) -
HAMMAR LENA,
HIRSCH IVAN,
MACHADO ALCYONE,
MAREUIL JEAN,
BAILLON JEAN,
CHERMANN JEANCLAUDE
Publication year - 1994
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1994.tb38907.x
Subject(s) - infectivity , mannan binding lectin , lectin , glycoprotein , mannan , antibody , virology , mannose , biology , human immunodeficiency virus (hiv) , ficolin , chemistry , virus , biochemistry , immunology , polysaccharide
Lectins with specificity for terminal mannose residues and anti-mannan antibodies are assumed to neutralize HIV-1 by binding to the viral glycoproteins. In this report we demonstrate that one such agents, the lectin from Galanthus nivalis (GNA), blocks infection also at the target cell level.