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Botulinum Toxin in the Treatment of Neurological Disorders
Author(s) -
DENIŠLIČ MIRO,
PIRTOŠEK ZVEZDAN,
VODUŠEK DAVID B.,
ZIDAR JANEZ,
MEH DUŠKA
Publication year - 1994
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1994.tb26615.x
Subject(s) - blepharospasm , focal dystonia , torticollis , botulinum toxin , spasmodic torticollis , medicine , ptosis , movement disorders , dysphagia , dystonia , diplopia , cervical dystonia , cerebral palsy , anesthesia , pediatrics , surgery , physical medicine and rehabilitation , psychiatry , disease
Botulinum toxin therapy is safe and effective in the treatment of different movement disorders, especially focal dystonias. We reviewed botulinum toxin treatment of 97 patients: 36 had blepharospasm, 41 had torticollis, and 20 had diverse movement disorders. Patients with blepharospasm and torticollis improved markedly after botulinum toxin injections. The most common side effect in BS patients was ptosis (44.4%); in TC patients, it was dysphagia (29.3%). The mean duration of the improvement in both groups was 3.4 months. Very promising results were obtained also in the heterogeneous group including patients with other focal dystonias and cerebral palsy. On the basis of these results, we concluded that BTA injections must now be considered the mainstay of therapy for focal dystonias and other involuntary movement disorders.