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Gene Therapy and Endothelial Cell Targeting for Cancer
Author(s) -
EVANS ROBERT R.,
CALMELS THIERRY P.,
PITT BRUCE R.,
BROOKENS MARGARET A.,
JOHNSON CANDACE S.,
MODZELEWSKI RUTH A.,
LAZO JOHN S.
Publication year - 1994
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1994.tb21717.x
Subject(s) - pittsburgh compound b , gerontology , st louis , medicine , library science , history , alzheimer's disease , art history , disease , computer science
The endothelium represents a potentially critical target for gene therapy because of its anatomical location and its importance in the viability in both normal and malignant tissues. Protecting the endothelium of normal tissues, such as the lungs, from the toxic effects of current antineoplastic agents and the destruction of the tumor vasculature are reasonable goals. As a target, however, the endothelium continues to represent a significant challenge. While gene delivery to cultured endothelial cells is possible, improved delivery systems are required, as well as cell-specific promoters, before in vivo gene therapy to important endothelial populations can be accomplished.