Premium
Novel Adjuvant Strategies for Experimental Malaria and AIDS Vaccines
Author(s) -
ALVING CARL R.,
DETRICK BARBARA,
RICHARDS ROBERTA L.,
LEWIS MARK G.,
SHAFFERMAN AVIGDOR,
EDDY GERALD A.
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb44015.x
Subject(s) - adjuvant , immunogenicity , malaria , malaria vaccine , vaccine adjuvant , broad spectrum , medicine , immunology , virology , plasmodium falciparum , immune system , chemistry , combinatorial chemistry
Adjuvant research has improved the ability of biotechnology to generate novel vaccines. Numerous strategies for enhancing the immunogenicity of synthetic peptides and proteins have been identified. This overview focuses on adjuvant development and vaccine delivery systems that provide new tools for amplifying the effectiveness of ongoing malaria and AIDS vaccine development programs. In addition, some of the complex challenges and issues that have become associated with the delivery of modern vaccines in man are outlined. As adjuvant research continues to open new opportunities in vaccine development, there is renewed expectation that further generations of safe and potent vaccines will be possible against a broad spectrum of infectious agents and cancer.