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Muscle GLUT 4 Protein Levels and Impaired Triglyceride Metabolism in Streptozotocin Diabetic Rats
Author(s) -
ŠEBÖKOVÁ E.,
KLIMEŠ I.,
MOSS R.,
ŠTOLBA P.,
WIERSMA M. M. L.,
MITKOVÁ A.
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb35710.x
Subject(s) - slovak , medicine , endocrinology , czech , philosophy , linguistics
Our data indicate that (a) the existence of a defect in the clearance of circulating TG and persistence of muscle TG deposition in the high sucrose-fed neonatal streptozotocin diabetic rat, which (b) can only be partially corrected by raised dietary n-3 PUFA intake. (c) Skeletal muscle of STZ type II-like diabetic rats contains about 40% less glucose transporters, and (d) this situation cannot be changed by any of the dietary treatments employed. (e) These findings indicate that muscle TG accumulation may have no direct relation to glucose transport in muscle.