Neurologic Syndromes

It is now well recognized that HIV-1 associated CNS disease may complicate the course of HIV-1 infection and AIDS in infants and children. It is also well recognized that the neurologic dysfunction in these young patients adds significantly to the morbidity of the disease and is often a devastating complication. It is apparent that HIV-1 CNS infection in infants and young children is complicated by numerous developmental issues. The effects, direct and indirect, of HIV-1 on the developing nervous system must be considered. The effects of HIV-1 on the immature immune system must also be considered. Moreover, the possible effects of HIV-1 on the many complex interactions between these two systems during development will clearly also require investigation. In order to care for these children and to design rational approaches for treatment and prevention, it is now critical to develop a better understanding of how HIV-1 affects the developing nervous system.