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Postulated Mechanisms Underlying the Development of Neural Tube Defects. Insights from in Vitro and in Vivo Studies a
Author(s) -
SULIK KATHLEEN K.,
SADLER T. W.
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb26106.x
Subject(s) - neural tube , teratology , mutant , biology , in vivo , neural development , neuroscience , function (biology) , developmental biology , embryo , neural tube defect , computational biology , process (computing) , genetics , cell fate determination , microbiology and biotechnology , gene , computer science , fetus , pregnancy , transcription factor , operating system
In recent years, use of animal models has resulted in acquisition of a significant amount of new information regarding normal and abnormal neural tube development. Studies of mutant and of teratogen-exposed mice are complementary, with each providing insights that promise to advance our understanding of the other. Analysis of teratogen-exposed embryos is best suited for identifying susceptible developmental stages and vulnerable populations. Advances in molecular genetics, with the ability to identify gene products, their cell/tissue location, and, potentially, to understand their function, will make naturally occurring as well as man-made mutants invaluable for understanding the heterogeneous mechanisms that underly NTDs.