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PKC Translocation in Rat Brain Cortex Is Promoted in Vivo and in Vitro by α‐Glycerylphosphorylcholine, a Cognition‐enhancing Drug a
Author(s) -
GOVONI S.,
BATTAINI F.,
LUCCHI L.,
PASCALE A.,
TRABUCCHI M.
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb23072.x
Subject(s) - in vivo , protein kinase c , in vitro , pharmacology , acetylcholine , chemistry , chromosomal translocation , cortex (anatomy) , biochemistry , kinase , microbiology and biotechnology , biology , neuroscience , gene
Protein kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain areas after treatment with α‐glycerylphos‐phorylcholine (GPC), a cognition‐enhancing drug which promotes acetylcholine synthesis and release. The drug induced both in vivo and in vitro PKC translocation. In vivo , an increase of paniculate PKC activity was observed 1 hour following the acute oral administration of a behaviorally active dose (600 mg/kg); the effect was transient. In vitro , GPC promoted PKC translocation in cortical slices at concentrations as low as 50 nM; the concentration‐response curve was bell shaped. The increased PKC activity may be related to the cortical effects of GPC.