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The βA4 Amyloid Protein Precursor in Human Circulation a
Author(s) -
BUSH ASHLEY I.,
BEYREUTHER KONRAD,
MASTERS COLIN L.
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb23048.x
Subject(s) - amyloid precursor protein , amyloid (mycology) , platelet , chemistry , biochemistry of alzheimer's disease , p3 peptide , disease , function (biology) , alzheimer's disease , protein precursor , amyloid precursor protein secretase , biochemistry , microbiology and biotechnology , biology , medicine , immunology , pathology , enzyme , inorganic chemistry
βA4, the principal constituent of the brain amyloid collections in Alzheimer's disease, is derived from a much larger precursor, the amyloid protein precursor (APP). APP exists in the blood as full‐length, potentially amyloidogenic forms in platelets, and as an attenuated species in plasma and T‐lymphocytes. Studies of circulating APP facilitate the elaboration of the function of this protein, as well as the elucidation of its processing in health and disease.