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NMDA Receptor Status in Elderly Normal Individuals and Those with Alzheimer's Disease a
Author(s) -
PORTER R. H. P.,
ROBERTS P. J.,
BRIGGS R. S. J.
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb23026.x
Subject(s) - nmda receptor , neuroscience , alzheimer's disease , receptor , medicine , psychology , disease
The status of NMDA receptors in the brains of normal aged individuals and those with Alzheimer's disease was investigated. The binding of [ 3 H]3‐((±)‐2‐carboxypiperazin‐4‐yl)propyl phosphonic acid ([ 3 H]CPP) to NMDA antagonist‐preferring sites on frontal and temporal cortical synaptic membranes was assessed. Binding could be resolved into two components, one of high and the other of low affinity. Pharmacologically, the two sites were qualitatively similar. Considerable intersubject variation in binding parameters was detected, but no significant differences were found between the mean values for the control and Alzheimer's disease groups. This study indicates that, when changes in receptor integrity occur in individual patients, these may be occluded because of the large variations between individuals.