Differences in Acetylholine Receptor‐Antibody Interactions between Extraocular and Extremity Muscle Fibers a | Zendy

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Differences in Acetylholine Receptor‐Antibody Interactions between Extraocular and Extremity Muscle Fibers a

Author(s) -

ODA KENICHIRO

Publication year - 1993

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1111/j.1749-6632.1993.tb22889.x

Subject(s) - extraocular muscles , christian ministry , annals , library science , citation , neurology , psychology , medicine , psychiatry , political science , classics , law , ophthalmology , art , computer science

There are two types of motor nerve innervation patterns and AChR distributions in human EOM: single and multiple. The latter is further divided into two subgroups that are restricted to EOM and are not found in limb muscles. Epitopes that are unique to EOM end-plates exist. Some OMG patients have antibodies that are specifically targeted to those epitopes. These antibodies are functionally active and can cause AChR loss in EOM end-plates. In addition to AChRs, specific components constructing the microenvironment surrounding them may also be involved in the susceptibility of EOM in myasthenia gravis.

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