Premium
From Proopiomelanocortin to Cancer
Author(s) -
MBIKAY MAJAMBU,
SEIDAH NABIL G.,
CHRETIEN MICHEL
Publication year - 1993
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1993.tb19671.x
Subject(s) - humanities , art
Melanophore-stimulating hormones (MSHs) are produced from a common precursor called proopiomelanocortin (POMC). These peptides have been at the center of studies on the prohormone theory since 1967. The recent discovery of endoproteases which can convert POMC to MSHs is having more biological implications than previously imagined, most particularly for proliferative diseases like cancer.