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Age‐Related Alterations of Isoproterenol‐Stimulated Adenylyl‐Cyclase Activity Are Partially Corrected by Thymic Graft
Author(s) -
VITICCHI CLAUDIO,
ROSSOLINI GIULIANA,
PIANTANELLI LUCIO
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb49104.x
Subject(s) - adenylyl cyclase , endocrinology , medicine , stimulation , adrenergic receptor , beta (programming language) , receptor , chemistry , in vivo , adrenergic , biology , microbiology and biotechnology , computer science , programming language
Previous experimental results have demonstrated progressive impairments in beta-adrenergic responsiveness with advancing age. Beta-adrenoceptors are involved in the alterations as their density progressively decreases during aging. Alterations in both in vivo responsiveness and receptor density are corrected by neonatal thymic grafts. In the present paper adenylyl-cyclase (AC) activity has been studied in the same animal models used before. Results show that no statistically significant changes can be observed when AC is assayed in absence of beta-adrenergic stimulation. On the contrary, when assayed after Isoproterenol stimulation, AC activity shows a shift of the peak and a decrease of its height in aged animals. A neonatal thymus grafted into old recipients one month before the experiment was performed, is capable of correcting the altered height of the peak but not the peak concentration.