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Modulation of the Oxidative Response of Cultured Mammalian Cells by L‐Histidine a
Author(s) -
SESTILI P.,
GIACOMONI P. U.,
GUIDARELLI A.,
CATTABENI F.,
CANTONI O.
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb38700.x
Subject(s) - history
Previous studies have demonstrated that L-histidine increases the fragmentation of \udpurified DNA induced by hydrogen per~xidel-~ as well as other effects produced by \udthe oxidant in cultured mammalian cells, such as cytotoxicity,'J chromosomal \udaberrations: sister chromatid exchange~,~J~~ and the formation of r n i c r o n u ~ l e i . ~ ~ ~ ~ ~ \udThe mechanism(s) involved in the enhancing effect of L-histidine on the deleterious \udeffects of hydrogen peroxide is (are) still controversial, although various hypotheses \udhave been made.- Summarized here are some of our recent results in studies to \udinvestigate the effects of L-histidin