Premium
Oxidant Carcinogenesis and Antioxidant Defense a
Author(s) -
CERUTTI PETER,
SHAH GIRISH,
PESKIN ALEXANDER,
AMSTAD PAUL
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb38659.x
Subject(s) - carcinogenesis , antioxidant , chemistry , pro oxidant , cancer research , medicine , biochemistry , gene
Growth promotion by oxidants is observed with cultured human and mouse fibroblasts as well as epidermal cells. It is expected to play a role in inflammation, fibrosis, and tumorigenesis. Indeed, oxidants trigger (patho)physiological reactions that resemble those induced by growth and differentiation factors. For example, active oxygen activates protein kinases. causes DNA breakage, and induces the growth competence‐related protooncogenes c‐ fos and c‐ myc.