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Stress Proteins and Reperfusion Stress in the Liver a
Author(s) -
BERNELLIZAZZERA ALDO,
CAIRO GAETANO,
SCHIAFFONATI LUISA,
TACCHINI LORENZA
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb38655.x
Subject(s) - heat shock protein , gene , hsp70 , microbiology and biotechnology , heat shock factor , gene expression , heat shock , transcription factor , biology , hsf1 , shock (circulatory) , cellular stress response , chemistry , fight or flight response , biochemistry , medicine
Blood reperfusion after temporary liver ischemia induces the expression of heat shock genes and the synthesis of heat shock proteins (hsps), in particular hsp 70. Induction requires a certain duration of ischemia, suggesting that cell damage before reperfusion is essential for activation of heat shock genes. The expression of the hsp 70 gene is preceded by activation of the cellular protooncogenes c-fos and c-jun. However, the product of these genes, which is transcription factor AP-1, seems unnecessary for activation of the hsp 70 gene, which does not require the integrity of protein synthesis. Hsp genes seem to behave as "early response genes," enabling the cell to respond to emergency situations.