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Effect of a Benzodiazepine Derivate Ro 15‐4513 on Ethanol‐Free Selection and CNS Mitochondrial Energetics in Rats
Author(s) -
EGAÑA ENRIQUE,
SALINAS ANTONIO,
RAMIREZ MARÍA TERESA
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb25991.x
Subject(s) - energetics , benzodiazepine , chemistry , pharmacology , ethanol , biochemistry , biology , receptor , ecology
1) Females are higher EtOH drinkers than males in E.F.S. experiments in rats. 2) Ro 15-4513 inhibited intake of EtOH. 3) Hypothalamus mitochondrial energetics, studied at Sites I and II, showed Ro 15-4513 inhibition of these parameters at different doses by sex: effects were seen in females at 15 mg and in males at 10 mg/kg rat/24 h. An uncoupled effect between electron transport and ADP/O was found.