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Alterations in Biodistribution of 11 C‐Methamphetamine (MAP), 14 C‐MAP, and 123 I‐ N ‐Isopropyl‐Iodoamphetamine (IMP) in MAP‐ and Cocaine‐sensitized Animals
Author(s) -
NUMACHI YOHTARO,
YOSHIDA SUMIKO,
INOSAKA TAKAO,
SATO MITSUMOTO,
MIZUGAKI MICHINAO,
KIMURA KATSUHIKO,
HISHINUMA TAKANORI
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb25964.x
Subject(s) - methamphetamine , forebrain , striatum , dopaminergic , biodistribution , behavioral sensitization , limbic system , chemistry , sensitization , isopropyl , neuroscience , pharmacology , endocrinology , medicine , biology , central nervous system , dopamine , biochemistry , nucleus accumbens , organic chemistry , in vitro
Alterations in brain distribution of 11C-MAP, 14C-MAP, and 123I-IMP in MAP- and cocaine-sensitized animals were examined to investigate the mechanism involved in increased dopaminergic transmission and behavioral sensitization. First, a significant increase in 11C-MAP radioactivity in the striatum and hypothalamus was found in the mice pretreated with MAP for 7 days. Secondly, in MAP-sensitized rats, marked increases in 14C-MAP radioactivity were found in the striatum and limbic forebrain, respectively (370% and 650%). These findings may propose a new hypothesis that subchronic MAP administration may result in a long-term change in the presynaptic cell membrane at the nerve terminal which may in turn cause an increase in both MAP and DA uptake accompanied by an increased release of DA at the synaptic cleft.