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IL‐5 Responsive Subsets among Normal and Lymphomatous Murine B Cells a
Author(s) -
TSIAGBE V. K.,
NICKNAM M. H.,
FATTAH D.,
THORBECKE G. J.
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb24624.x
Subject(s) - microbiology and biotechnology , chemistry , physics , biology
Two normal murine B-cell subpopulations, germinal center and coelomic B cells, and at least some of the lymphomas derived from them, respond to IL-5. In the case of normal B cells, a comitogen (DxS) is required. IFN-gamma is strongly inhibitory to proliferation of the coelomic B-cell subset but not for germinal center cells or the SJL lymphomas derived from them.