Premium
Development of γδ T‐cell Subsets from Fetal Hematopoietic Stem Cells a
Author(s) -
IKUTA KOICHI,
KINA TATSUO,
MacNeil IAN,
UCHIDA NOBUKO,
PEAULT BRUNO,
CHIEN YUEHHSIU,
WEISSMAN IRVING L.
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb24590.x
Subject(s) - fetus , haematopoiesis , stem cell , bone marrow , biology , immunology , microbiology and biotechnology , pregnancy , genetics
Hematopoietic stem cells (HSC) were isolated from mouse fetus, and their developmental potential was compared with adult HSC. Donor-derived V gamma 3+T cells were detected in fetal thymic lobes, repopulated in vitro with fetal liver HSC, but not in those with adult bone marrow HSC. Single clonogenic fetal HSC gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSC. These results support a hypothesis that only fetal HSC have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment, and that the developmental potential of HSC may change during ontogeny.