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CGRP as a Marker of the Climbing Fibers during the Development of the Cerebellum in the Rat
Author(s) -
MORARA S.,
ROSINA A.,
PROVINI L.
Publication year - 1992
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1992.tb22800.x
Subject(s) - climbing fiber , cerebellum , calcitonin gene related peptide , neuroscience , cerebellar cortex , inferior olivary nucleus , synapse , anatomy , chemistry , biology , neuropeptide , receptor , biochemistry
Olivary fibers express CGRP-LI until the nest phase of their development and never in the next postnatal steps, that is, the "capuchon" stage. Together with other results presented in this volume regarding the postnatal development of CGRP binding sites in the cerebellar cortex, these immunohistologic findings suggest a role for CGRP in reshaping connectivity and in synapse stabilization of cerebellar circuitry during postnatal development.