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Initiation of the Protein C Pathway
Author(s) -
ESMON CHARLES T.,
JOHNSON ARTHUR E.,
ESMON NAOMI L.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb43689.x
Subject(s) - thrombomodulin , protein c , inflammation , coagulation , receptor , thrombin , immunology , inflammatory response , medicine , microbiology and biotechnology , biology , bioinformatics , cancer research , neuroscience , chemistry , platelet
The protein C activation system provides an interesting model for the control of coagulation. Expression of the critical receptor appears to be under the control of inflammatory mediators. Open questions of considerable importance relate to the physiological significance of these observations. Preliminary evidence is emerging that thrombomodulin is down-regulated in patients and animals with inflammation, but it remains to be determined if the loss of thrombomodulin causes the thrombotic complications or occurs in response to these complications.