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Insulin‐like Growth Factor‐II (IGF‐II) and IGF Binding Proteins in Human Endometrium a
Author(s) -
GIUDICE LINDA C.,
LAMSON GEORGE,
ROSENFELD RON G.,
IRWIN JUAN C.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb37924.x
Subject(s) - paracrine signalling , autocrine signalling , endometrium , endocrinology , medicine , stromal cell , growth factor , insulin like growth factor , insulin like growth factor binding protein , receptor , biology , chemistry , steroid hormone , secretion , microbiology and biotechnology , hormone
The insulin-like growth factor autocrine/paracrine system is believed to play a role in steroid-mediated endometrial differentiation. It is constituted of the mitogenic peptides (IGF-I and IGF-II), membrane receptors, and a family of high-affinity binding proteins (IGFBPs) that regulate the actions of the IGFs at their target cells. We have investigated expression of the mRNAs encoding the three major IGFBPs (IGFBP-1, IGFBP-2, and IGFBP-3) in human endometrium and have found, by Northern analysis, differential expression of all three mRNAs in secretory compared to proliferative endometrium, different steroidal milieux. IGF-II mRNAs were also detected in secretory endometrium. Finally, we found that human endometrial stromal cells in culture synthesize and secrete IGFBP-2 and IGFBP-3, and that the synthesis of IGFBP-2 is regulated by steroid hormones.