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Effects of Insulin‐like Growth Factor I and Growth Hormone in Cultured Human Granulosa Cells a
Author(s) -
BERGH CHRISTINA,
CARLSSON BJÖRN,
OLSSON JANHENRIK,
BILLIG HÅKAN,
HILLENSJÖ TORBJÖRN
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb37911.x
Subject(s) - obstetrics and gynaecology , medicine , university hospital , gynecology , obstetrics , biology , pregnancy , genetics
Human granulosa cells, obtained either from natural or stimulated cycles, were cultured, and the response to IGF-I and GH was analyzed. It was found that IGF-I alone stimulated thymidine incorporation in both types of granulosa cells. Furthermore, IGF-I alone and in combination with FSH or LH enhanced estradiol and progesterone production. In a limited series of experiments, GH in combination with FSH was found to stimulate steroidogenesis in granulosa cells obtained from natural, but not from stimulated, cycles.