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Evidence for 5‐Hydroxyeicosatetraenoic Acid (5‐HETE) and Leukotriene C 4 (LTC 4 ) in the Onset of Labor a, b
Author(s) -
WALSH SCOTT W.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb37879.x
Subject(s) - hydroxyeicosatetraenoic acid , leukotriene , chemistry , radiochemistry , lipoxygenase , medicine , biochemistry , asthma , enzyme
Arachidonic acid is metabolized by cyclooxygenase leading to prostaglandins (PG), and by lipoxygenases leading to hydroxyeicosatetraenoic acids (HETE) and leukotrienes (LT). PGs are potent uterine constrictors. 5-HETE and LTC4 also stimulate uterine contractions, but their role in labor is not known. To estimate the activities of these pathways before parturition and their relationship to uterine contractility, amniotic fluid (AF) concentrations of 5-HETE, LTC4 and PGF2 alpha were determined in 5 chronically catheterized rhesus monkeys. Uterine contractility was continually assessed by changes in AF pressure.