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Halothane‐Induced Alteration in the Fluidity of Rat Brain Synaptosomal Membranes and Its Relationship to Anesthesia a
Author(s) -
SASTRY B. V. RAMA,
FRANKS JOHN J.,
SURBER MELANIE J.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb33872.x
Subject(s) - halothane , membrane fluidity , anesthesia , chemistry , membrane , medicine , biochemistry
Concentrations of halothane 1.43% or higher abolished the pain response and induced anesthesia. Halothane increased membrane fluidity of synaptosomes and microsomes both at non-anesthetic and anesthetic concentrations. Changes in fluidity in synaptosomes did not return to control levels even after the animals recovered from anesthesia. Alteration in membrane fluidity by halothane is a non-selective effect and may not play a definitive role in anesthesia.