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Autoregulation of the Immune Response in Autoimmune Disease and Cardiac Transplantation by Photoinactivated Autologous Lymphocytes
Author(s) -
BERGER CAROLE L.,
EDELSON RICHARD L.,
EDWARDS NILOO,
SANCHEZ JUAN,
COPPEY LARRY,
HE XU,
MARBOE CHARLES,
ROSE ERIC
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb33457.x
Subject(s) - immune system , immunology , medicine , effector , transplantation , autoregulation , disease , autoimmune disease , dysfunctional family , antibody , pathology , blood pressure , clinical psychology
These studies demonstrate that photochemotherapy can be successfully evaluated in animal models. The therapy mediates specific suppression of immune responses and appears to operate at the level of the effector T cells. Future studies will focus on isolation and characterization of the host response to photochemotherapy. The extention of this form of therapy to conditions mediated by dysfunctional regulation of effector T cells is already in progress in clinical trials of cardiac allograft transplantation and autoimmune disease. The results of these trials will provide more evidence on the role of this form of therapy in autoregulation of the immune response.