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Accessory Cell‐Derived Costimulatory Signals Regulate T Cell Proliferation a
Author(s) -
URDAHL KEVIN B.,
JENKINS MARC K.,
NORTON STEVEN D.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb33436.x
Subject(s) - medical school , library science , gerontology , medicine , computer science , medical education
The costimulatory effects of anti-CD28 antibody or accessory cells on T cells were shown to be very similar. Both stimuli: (a) allowed T cell proliferation and IL-2 production in response to immobilized anti-CD3 antibody or antigen presented by APC whose costimulatory capacity had been damaged by fixation; and (b) stimulated cyclosporin A-resistant T cell proliferation in the presence of a phorbol ester. These similarities raise the possibility that anti-CD28 antibody binding to T cells delivers a costimulatory signal that is normally delivered by the interaction of CD28 with a complementary ligand on APC.