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Kinetic Models of Na‐Ca Exchange in Ferret Red Blood Cells
Author(s) -
MILANICK M. A.,
FRAME M. D. S.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb17358.x
Subject(s) - limiting , chemistry , intracellular , red blood cell , biophysics , biochemistry , biology , mechanical engineering , engineering
The kinetic equation that best describes the intracellular Na dependence of Ca influx into ferret red cells is sequential; whether this implies that there is a conformation of the protein that has both Na and Ca ions bound remains to be determined. Cd and Mn substitute very well for Ca on the exchanger in ferret red cells; this suggests that the Ca-binding site does not contain an important thiol and that the one of the Na steps may be rate limiting.