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Generation of T Cell Lines with Suppressive Activity Derived from Autorosette‐Forming Cells of Patients with Autoimmune Diseases
Author(s) -
KALECHMAN Y.,
MICHLIN H.,
GAFTER U.,
SREDNI B.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb17272.x
Subject(s) - tel aviv , medicine , library science , theology , philosophy , computer science
A unique subpopulation of human suppressor autorosette-forming T cells was fractionated from peripheral blood of healthy donors and patients with various immune disorders. These cells have been maintained in long-term cultures and evinced suppressor activity in their supernatants. The study indicates the existence of a competitive relationship between the suppressor factors secreted by the cell lines and IL-2. It was found that impaired suppressor function can be related to a decrease in suppressors cell number, impaired function of individual suppressor cells, or failure to respond to active suppressor factors.