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Antagonism of the Inhibitory Effects of Transforming Growth Factor‐β on Colony Formation of Mouse Bone Marrow Cells in Vitro by Increasing Concentrations of Growth Factors a
Author(s) -
BRADLEY T. R.,
MILLAR J. L.,
BERTONCELLO I.,
POWLES R. L.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb17222.x
Subject(s) - antagonism , in vitro , transforming growth factor , bone marrow , chemistry , inhibitory postsynaptic potential , microbiology and biotechnology , growth factor , biology , immunology , endocrinology , biochemistry , receptor
Low concentrations of TGF-beta inhibited the clonal proliferation of three different preparations of mouse bone marrow progenitor cells in vitro. Normal marrow cells responsive to CSF-1; two-day post-fluorouracil cells responsive to CSF-1 plus IL-3 and IL-1 alpha; and regenerating seven-day post-fluorouracil cells responsive to CSF-1 plus IL-3, IL-1 alpha and IL-6 were all severely inhibited by TGF-beta 1; and the inhibitory effects were antagonized by increasing the concentrations of the relevant growth factors.