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Role of Transforming Growth Factor‐β1 in Regulation of Hematopoiesis a b
Author(s) -
RUSCETTI FRANCIS W.,
JACOBSEN STEN E.,
BIRCHENALLROBERTS MARIA,
BROXMEYER HAL E.,
ENGELMANN GARY L.,
DUBOIS CLAIRE,
KELLER JONATHAN R.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb17220.x
Subject(s) - cancer , research center , library science , center (category theory) , gerontology , medicine , political science , law , computer science , chemistry , crystallography
The data presented above suggest that one possible clinical use of TGF-beta would be to protect the bone marrow from the effects of myelosuppressive chemotherapeutic drugs by preventing entry or removing primitive stem cells from the cell cycle. It may also have the additional benefit of reducing the drug-induced neutrophil nadir by stimulating granulopoiesis. The availability of large quantities of recombinant TGF-beta will allow study of the pharmacokinetics with different routes of administration, dosage effects, and details of the pleiotropic effects on other cell systems. Experiments are in progress to determine whether TGF-beta will allow the delivery of higher amounts or more frequent doses of chemotherapeutic drugs and thus allow increased antitumor efficacy in tumor-bearing animals.