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Protease Injury in Airways Disease
Author(s) -
RENNARD STEPHEN I.,
RICKARD KATHLEEN,
BECKMANN JOE D.,
HUERTA GUILLERMO,
KOYAMA SEKIYA,
ROBBINS RICHARD A.,
ROMBERGER DEBRA,
SPURZEM JOHN,
THOMPSON AUSTIN B.
Publication year - 1991
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1991.tb17026.x
Subject(s) - proteases , airway , protease , respiratory epithelium , disease , medicine , immunology , biology , pathology , enzyme , biochemistry , surgery
In summary, proteases are present in the airway in inflammatory airways disease. These enzymes can damage the airway epithelium. As a consequence, airway function can be altered, and long-term changes in airway anatomy can result. Although the exact cellular and biochemical mechanisms that lead to these changes are incompletely described, it seems likely that they will play important roles in clinical airways disease. As such, these pathways may represent novel opportunities for therapeutic intervention.